| Date | Opponent | Location | Outcome/Time |
| 08/30/2008 | Illinois | St. Louis, MO | W, 52-42 |
| 09/06/2008 | Southeast Missouri State | Columbia, MO | W, 52-3 |
| 09/13/2008 | Nevada | Columbia, MO | W, 69-17 |
| 09/20/2008 | Buffalo | Columbia, MO | W, 42-21 |
| 10/04/2008 | Nebraska | Lincoln, Nebraska | W, 52-17 |
| 10/11/2008 | Oklahoma State | Columbia, MO | L, 23-28 |
| 10/18/2008 | Texas | Austin, TX | L, 31-56 |
| 10/25/2008 | Colorado | Columbia, MO | W, 58-0 |
| 11/01/2008 | Baylor | Waco, TX | W, 31-28 |
| 11/08/2008 | Kansas State | Columbia, MO | W, 41-24 |
| 11/15/2008 | Iowa State | Ames, Iowa | W, 52-20 |
| 11/29/2008 | Kansas | Kansas City, MO | L, 37-40 |
| 12/06/2008 | Oklahoma | Kansas City, MO | L, 21-62 |
| 12/29/2008 | Northwestern / Alamo Bowl | San Antonio, TX | W, 30-23 (OT) |